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What distinguishes ipamorelin from earlier GHRPs is its receptor selectivity

Vahmani P, Meadus WJ, Duff P, Rolland DC, Dugan ME

Antinociceptive and Analgesic Effects DSIP demonstrated a potent antinociceptive effect when administered intracerebroventricularly or intracisternally in rodent models establishing central analgesic activity independent of peripheral opioid mechanisms