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Ricciarelli and Fedele, 2017)

In March 2011, the FDA placed the trial on clinical hold due to GMP compliance issues at the contract manufacturer not safety concerns with RGN-352 itself

It reduced magnetic resonance imaging-proton density fat fraction (MRI-PDFF) by -20.266 (95% CI: -35.806 to -4.726, P=0.01) and decreased enhanced liver fibrosis score (baseline 9) by -0.234 (95% CI: -0.441 to -0.027, P=0.03)

Data depict peak intensity of the M + 1 isotopologue of UMP ( n = 4 per group, p for EV +Urd-WT +Urd = 0.0003, p for EV +Urd-EV -Urd = 0.0004, p for WT +Urd-WT -Urd = 0.0318, p for EV -Urd-WT -Urd = 0.0011)

Further studies are required to elucidate the optimal conditions, formulations, and dietary adjuncts that maximize PCs efficacy in diabetes management