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The application of low-frequency ultrasound initiates periodic oscillations (stable cavitation) within the blood vessels, resulting in the generation of mechanical stress

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The starting dose of 2.5 mg is maintained for four weeks, followed by 5 mg for four weeks, then 7.5 mg, 10 mg, 12.5 mg, and finally 15 mg

Thus, blocking the HGF/c-Met/mTOR signaling pathway can inhibit cancer cells invading and migrating along nerves and may be a therapeutic target for PNI in pancreatic cancer