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Rats were administered porcine type II collagen and treated orally with CaME (50, 150, and 250 mg/kg/day) for 15 days, and the outcomes were measured

Histopathological findings were evaluated by consensus among experienced pathologists

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Additionally, we have developed a liposomal nanoparticle system for delivering PGC-1 siRNA and assessed its transfection efficiency, cytotoxicity, and impact on gene expression in bladder cancer cells

Significant parameters that will influence the effectiveness of MSCs must be considered before conducting large-scale trials, including cell source, the donor and recipient, route, dose and time of administration, and pretreatment of MSCs, to maximize their therapeutic efficacy while minimizing potential side effect