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Furthermore, these results are consistent with previous 1 H-MRS studies in humans that found IV ketamine elevates ACC glutamine and Glx immediately 9,10 and ACC glutamate levels after 35 min in healthy individuals 8 , together with studies in patients with MDD that reported an acute mPFC Glx increase 11 and an increase prefrontal 13 C-glutamine 13 following IV ketamine administration

Conversely, reducing KYNA through targeted KAT deletion enhances hippocampal glutamatergic tone, improving cognitive performance and synaptic plasticity [30]

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