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Abbreviations ALS: Amyotropic lateral sclerosis AMPA: -Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid BBR: Berberine ChAT: Choline acetyltransferase CK: Creatinkinase CNS: Central nervous system CSA: Chinese scalp acupuncture DATS: Diallyl trisulfide DNA: Deoxy ribonucleic acid EGCG: Epigallocatechin gallate EMG: Electromyography studies FDA: Food and drug administration FVC: Forced vital capacity HupA: Huperzine A IBM: Inclusion body myositis, S Lf: Lactoferrin LMN: Lower motor neurons LPS: Lipopolysaccharide MEP: Motor evoked potentials MN: Spinal motoneuron, MND: Motor Neuron Disease MPP: 1-Methyl-4-phenylpyridinium MRI: Magnetic resonance imaging MSC: Mesenchymal stromal cells NAD: Nicotinamide adenine dinucleotide ND: Neurodegenerative disease NGF: Nerve growth factor NLRP3: NOD-like receptor pyrin domain-containing-3 NMDA: N -Methyl-D-aspartate NR: Nicotinamide riboside PM: Polymyositis PT: Pterostilbene RBP: RNA binding protein ROS: Reactive oxygen species SOD: Superoxide dismutase TMC: N -Trimethylated chitosan UMN: Upper motor neurons US: United States WFA: Withaferin A References Ahmed T, Gilani AU, Abdollahi M, Daglia M, Nabavi SF, Nabavi SM (2015) Berberine and neurodegeneration: a review of literature

refrigeration recommended to maintain stability Handling Details: Use appropriate laboratory safety protocols including gloves and eye protection

doi: 10.1007/s11357-019-00100-3 208 MaM.JiangW.ZhouR

By analyzing how drugs affect cellular and tissue-level processes, researchers can elucidate mechanisms of action and refine strategies for drug design and screening

doi: 10.1371/journal.pone.0113257