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109 The combination of intestinal microbiome therapies such as antibiotics, probiotics, FMT and bacterial genetic engineering with the therapeutic strategy of ICI provides new possibilities for the treatment of intestinal microbiota

Spine (Phila Pa 1976) 42 (Suppl 24), S103S107

has received honoraria from Daiichi Sankyo and serves on the Scientific Advisory Board of Akebia Therapeutics, a company that develops prolyl 4-hydroxylase inhibitors for the treatment of renal anaemia

Research has indicated that when iron ions are present at specific concentrations, they can inhibit the activity of Runt-related transcription factor 2 (Runx2), a critical regulator of osteoblast differentiation ( Figure 2 )

renal excretion is minor