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To decipher the exact subcellular localization of AuNPs-d-PLL-PEG-FA.siRNA 50 nM, cells were incubated with the NP complexes for 4 hours at 37 C

doi: 10.3389/frph.2022.822257 Received 25 November 2021 Accepted 17 January 2022 Published 22 February 2022 Volume 4 - 2022 Edited by Roland Eghoghosoa Akhigbe, Ladoke Akintola University of Technology, Nigeria Reviewed by Giulia Collodel, University of Siena, Italy

This conversion process allows l-citrulline to maintain higher plasma l-arginine concentrations compared to direct l-arginine supplementation

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Moreover, it exerted an interesting antioxidant activity by inducing SOD, GPx, mitochondrial respiratory enzyme complexes I, II, IV, promoting ATP and factors involved in mitochondrial biogenesis