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Randomized phase II study of modified FOLFOX-6 in combination with ramucirumab or icrucumab as second-line therapy in patients with metastatic colorectal cancer after disease progression on first-line irinotecan-based therapy

Glutamate Our earlier study showed that treatment of HT22 cells with glutamate activates PDI-mediated nNOS dimerization, which is followed by accumulation of NO and ROS, and ultimately, ferroptotic cell death [8, 40]

Among them, system Xc (including SLC7A11 and SCL3A2), which are expressed at the cell membrane, are easier to be detected as a cell surface marker of cells undergoing ferroptosis

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