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Description

On-treatment analysis showed weight loss of 22.7% with CagriSema, approaching the efficacy of bariatric surgery

The trial identifier is NCT07437547

In biochemical and preclinical models, the peptide appears to regulate endothelial activity, cell migration, and cytoskeletal organization through interactions with kinase signaling cascades and nitric oxide related mechanisms

The approval was backed by the Phase II open-label AGAVE-201 trial, where treatment with a 0.3-mg/kg dose of Niktimvo elicited an overall response rate of 75%, with a median time to response of 1.5 months