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*Correspondence: Zuzana Pilsova, [email protected]

Some important characteristics: The main determinant of intravascular oncotic pressure Produced by the liver Its half-life is approximately 17-21 days Aside from its role in maintaining oncotic pressure, albumin has many other important roles: Helps permit solubilization and transport of various molecules Calcium, magnesium, copper, zinc Drugs (warfarin, NSAIDs) Long chain fatty acids Toxic metabolites (unconjugated bilirubin) Inflammatory mediators (e.g., in sepsis) Antioxidant capacity Acts as a free radical scavenger for reactive oxygen species Neutralizes free copper, iron Immunomodulation Systemic inflammatory responses can be triggered by immune recognition of pathogen-associated molecular patterns (PAMPs are unique microbial-specific antigens such as lipopolysaccharide or peptidoglycans) and damage-associated molecular patterns (DAMPs, endogenous substances such as mitochondrial DNA released by dying cells)

doi:10.1113/JP278473 Sadaka A, Nguyen K, Malik A, Brito R, Berry S, Lee AG

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