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Immunity 37 , 563573 (2012)

Resveratrol protects myocardial ischemia-reperfusion injury through both NO-dependent and NO-independent mechanisms. Free Radic Biol Med 36 (2004): 774-781

Semaglutide is approved (Wegovy 2021, Ozempic 2017)

Blood levels rise across the first several weekly doses and settle near steady state after about four weeks. That is why the four-week hold matters: the full effect of a dose change is not visible in the first few days