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PEM is also thought to be linked to insufficient ATP levels due to a lack of available adenosine, which delays the rapid replenishment of ATP stores post-exercise and may contribute to prolonged recovery times observed in these patients following physical exertion (Lengert and Drossel, 2015)

Heart, liver, kidney and brain tissues were rapidly removed and clamped frozen at liquid N 2 temperature and stored at80 C

It is a strong anti-oxidant that is toxic to melanocytes hence by reducing these cells, it reduces melanin production

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For instance, the breakdown of histidine in the gut produces imidazole propionate (IMP), which accumulates in the kidney