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Hepatocellular injury pattern and pediatric incidence were associated with worse outcomes

In addition, binding of tryptophan metabolites to aromatic hydrocarbon receptors can counteract signals that activate T cells, leading to immune escape by tumor cells 36,37

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Previous work suggested that only about 50% of all PD patients have a distribution of LBP in the brain that is entirely consistent with the Braak staging model, a prerequisite for the assumption that iLBD is a precursor for SNc pathology in PD [29, 214, 215], and about half of PD cases do not seem to show a caudo-rostral spread of LBP throughout the brain [216]