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doi: 10.7759/cureus.56579 165 Van den HouteKColomierERouthiauxKMarienZScholJVan den BerghJet al

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The mechanism appears to involve increased serotonin synthesis in substantia nigra (both compacta and reticulata), a regional pattern unlike any existing antidepressant drug, plus potential dopaminergic contributions given the nigrostriatal location