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The ranges below are extrapolated from rodent studies scaled to human bodyweight using allometric conversion, and reflect the most commonly cited research-protocol doses in the practitioner literature

1 Introduction Radiotherapy, a pivotal treatment modality for cancer, is employed in more than 50% of the cases in curative and palliative care ( While most current research focuses on the care of acute radiation dermatitis, there remains a significant unmet need for more effective interventions targeting the prevention and treatment of chronic radiation-induced skin fibrosis

Circulation effects on angiogenesis and local blood supply have been described

The dermis was then carefully separated from the full-thickness skin specimens and soaked in collagenase solution (collagenase C7657 Sigma, 2 mgmL 1 ) at 37 C for 1 h with gentle agitation

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