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Biochemistry 119 , 817822 (1996)

Increased levels of TFAs may also contribute to the pathogenesis of mental disorders as a result of altering the neuronal lipid membrane composition, leading to reduced levels of polyunsaturated fatty acid content, reduced membrane fluidity, and impaired neurotransmission (28, 30, 31)

If not repaired, these oxidative lesions to DNA would interrupt the sequence of events involved in the propagation of epigenetic signals, thus leading to dysregulation of transcriptional activity