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I spoke to a friend at work and she had a similar skin reaction after her 2nd Moderna shot as well

This suggests that the level of expression and activity of these two integrins could essentially create on/off switches in the TM/SC pathway that could regulate the homeostatic properties of the tissue

Cell 167 , 9851000.e1021 (2016)

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A: It is better to think of it as influencing the signaling environment that supports remodeling, rather than treating it like a simple collagen switch