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Of special relevance to our study, RNR consumes reducing equivalents supplied by GSH, as well as thioredoxin, in mammalian cells (Zahedi Avval & Holmgren, 2009

Together, these observations strongly support the proposed role of iNOS and NO in mediating erastin-induced ferroptotic cell death in cultured hepatocytes

Electron transport through the complexes is coupled to proton translocation via the mitochondrial inter membrane space, forming an electrochemical proton gradient (electromotive force) and a mitochondrial transmembrane potential ( m ), necessary for generation of ATP

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