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The top phytochemical interactions with the protein were computed using the relevant RMSD, RMSF, Hydrogen Bond, Solvent Accessible Surface Area and Radius of Gyration values

That should give you a better understanding of what causes B12 side effects

According to the National Institutes of Health (NIH), vitamin B12 deficiency can cause numerous symptoms like fatigue, neurological changes, megaloblastic anemia, palpitations, and low white and red blood cell counts

The efflux of Cl and also the organic osmolytes during regulatory volume decrease (RVD) are mainly mediated by VRACs (Abdullaev et al., 1990)

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