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Motherwell, William B

Red Crescent Med

Here, Ekihiro Seki & team implicate the fungal sensing adaptor protein CARD9 in maintaining gut barrier integrity under metabolic stress, finding that the loss of fungal sensing exacerbates liver injury in a murine model of MASLD

Ripe fruit of other 11 Chinese bayberry cultivars were obtained from the variety repository of Fruit Research Institute in Fujian province, China, including Baxiandao, Dongkui, Fenhong, Fugongyihao, Heijing, Longhaishuijing, Luozi, Ruansianhaibian, Shuijing, Tezaomei, and Wumei. Three biological replicates were collected, with each replicate including 20 fruit, five fruit, and 30 g for fruit at early developmental stages (S1 and S2), fruit at late developmental stages (from S3 to S6) and other tissues, respectively

Furthermore, ChIP assays demonstrated that Np63 directly binds to the gene promoters or enhancers of PHGDH, PSAT1, PSPH and SLC1A4 (Fig