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However, this results in negative energy balance to the host and production of reactive oxygen species (ROS) that harms the healthy tissue but not the tumor cells, which have high ability to produce antioxidants through an intermediate metabolite from the lactate formation (NADPH NADP + H + ) (66)

Q: How about the delivery time

elegans aggresome-like organelles we identified are juxtanuclear, HttPolyQ aggregate-enriched, and dependent upon orthologs of mammalian aggresome adaptor proteins, dynein motors, and microtubule integrity for localized aggregate collection