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Larger doses of either Tylenol or alcohol, and especially both at the same time, can also increase the risk and severity of the side effects and risks

J Pharmacol Exp Ther 241:527533 Roberts DW, Bucci TJ, Benson RW, Warbritton AR, McRae TA, Pumford NR, Hinson JA (1991) Immunohistochemical localization and quantification of the 3-(Cystein- S -yl)-acetaminophen protein adduct in acetaminophen hepatotoxicity