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Proc Natl Acad Sci USA 103(26):1003510040

When comparing all tumours with GC excess (n=15) to the remaining inactive and non-GC-secreting tumours (N=28), LEF-1 expression was significantly higher in GC-producing tumours (comprising GC and GCA) compared to non-GC-producing tumours with a median H-score of 70 ( Figure 6D ), but we did not observe a significant difference for CTNNB1 ( Figure 6E ) or GR ( Figure 6F ) expression in our dataset, respectively

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TCA cycle Answer D: Fatty acid synthesis requires NADPH derived from the PPP via the oxidation of G6P