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The most significant changed plasma metabolites in MS-affected Chinese patients were amino acid, lipid and their derivatives, of which representative differentially abundant metabolites such as L-glutamic acid, L-leucine and L-isoleucine, as well as sphingosine 1-phosphate and sphinganine 1-phosphate, were also identified in Caucasian populations with MS (26, 44, 107)

It's also present in some diuretics like hydrochlorothiazide, some diabetes medications like glyburide, and some pain relievers like celecoxib

USP33 deubiquinates arrestin3 under desensitization conditions Given that arrestin deubiquitination is observed under desensitization conditions [35], we next tested whether arrestin3 deubiquitination is actively performed by a deubiquitinase

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