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In vivo imaging by cSLO and SD-OCT observed the pathological changes of the retina, especially in the inner nuclear layer, outer nuclear layer and retinal pigment epithelial layer, caused by sodium iodate

A recent clinical trial examining the hepcidin mimetic, Rusfertide (PTG-300), for use in hereditary hemochromatosis demonstrated reduction in both transferrin saturation and serum iron during treatment, reduced requirement for phlebotomy during the study period, and resulted in control of hepatic iron concentration [163]

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Collectively, these studies underscore the pivotal role of -syn in PD-related ferroptosis and neurodegeneration, providing a rationale for therapeutic strategies targeting ferroptosis

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