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Our major finding showed high serum and urine PyroGlu levels in critically ill patients

Therefore, by activating this NCOA4-mediated ferritinophagy pathway, Erastin promotes the release of free iron, which in turn amplifies ROS production and lipid peroxidation, resulting in an autophagy-dependent mode of ferroptosis

These observations suggest that diminished PON1 activity may be a more generalizable marker of systemic oxidative burden than a disease-specific phenomenon

The effect of a chronobiological feeding model on growth parameters and length of hospitalization in preterm infants: a randomized controlled study

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