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Obesity increases adipocyte development and cell hypoxia, which stimulates inflammatory chemokines and cytokines via HIF1 in adipose tissue macrophages (ATMs), inducing their polarization into the M1 phenotype (Shi et al., 2006)

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Souilem F, Fernandes , Calhelha RC, Barreira JCM, Barros L, Skhiri F, Martins A, Ferreira ICFR (2017) Wild mushrooms and their mycelia as sources of bioactive compounds: antioxidant, anti-inflammatory and cytotoxic properties

[DOI] [Google Scholar] 137.Song W., Wei F., Gao S., Dong C., Hao J., Jin L., Li F., Wei P., Guo J., Wang R

Prodrugs are molecules with little pharmacological activity that permit conversion to active native drugs in vivo by chemical or enzymatic reactions