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Description

The adjacent His residues at positions 13 and 14 of A42 conceivably could provide bidentate ligand binding of Cu 2+

2020;48(D1):D2658

A is generated through sequential cleavage of amyloid precursor protein (APP) by -secretase 1 (BACE1) and -secretase (Guillemot et al., 2013)

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In cell and tissue models, Epithalon upregulates telomerase activity, maintains telomere length, and modulates aging-related gene expression (p16, p21) to delay senescence