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Jul 2014;16(7):577-87

Thus, dysfunctional carbonylated proteins accumulate as covalently crossed protein aggregates, making them highly resistant to proteolysis, thereby affecting the functional integrity of cells during the aging and disease processes

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Lack of insulin receptor signaling in Leprechaunism may result in the rare event of an alive but severely small for gestational age baby that will only survive if treated with recombinant-IGF-1 to substitute inulin receptor signaling with IGF1R signaling via their common intracellular pathways