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In this mouse model, 7585% decrease of Gpx4 was shown to induce hippocampal neuronal loss, lipid peroxidation, neuroinflammation and spatial learning deficits (Hambright et al., 2017)

doi: 10.1517/17425255.2.3.351 99 YamasakiMMakinoTMasuzawaTKurokawaYMiyataHTakiguchiSet al

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At 428.303(c)(5), we proposed that if a manufacturer believes a generic Part D rebatable drug that was granted a reduction of the rebate amount and continues to be affected by the potential drug shortage continuing into 1 additional consecutive applicable period, the manufacturer may request an extension of the rebate reduction one time by submitting a rebate reduction extension request and supporting documentation