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To address the need for independent validation, we systematically evaluated all lead variants in publicly available POAG GWAS datasets, including UK Biobank (European ancestry), POAAGG (African ancestry), and other published studies identified through the GWAS Catalog

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Similarly, in a retrospective study of 80 patients with metastatic melanoma who received a combined CTLA-4 and a PD-1 inhibitor, patients who developed irAEs warranting treatment discontinuation were later rechallenged with a single-agent PD-1 inhibitor

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