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This observation supports the beneficial effect of dietary folate supplementation to increase SAM production in women before conception and early gestation [174]

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Available online at: Summary Keywords autism spectrum disorder, amino acids, mammalian target of rapamycin, nutritional intervention, gut-immune-brain axis Citation van Sadelhoff JHJ, Perez Pardo P, Wu J, Garssen J, van Bergenhenegouwen J, Hogenkamp A, Hartog A and Kraneveld AD (2019) The Gut-Immune-Brain Axis in Autism Spectrum Disorders

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