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[DOI] [PMC free article] [PubMed] [Google Scholar] Pawlak 2013 Pawlak R, Parrott SJ, Raj S, CullumDugan D, Lucus D

(en) Tshiko Takahashi-Iiguez, Enrique Garca-Hernandez, Roberto Arregun-Espinosa et Mara Elena Flores, Role of vitamin B 12 on methylmalonyl-CoA mutase activity , Journal of Zhejiang University SCIENCE B , vol

Notes that alternative pathways such as polyamine biosynthesis could compensate for raised SAM, that partial rather than total inhibition may be preferable to avoid compensatory mechanisms from an imbalanced SAM/SAH ratio, and that the consequences of sustained NNMT inhibition on systemic epigenetics remain unclear