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A methionine-restricted diet can suppress tumor growth in cholangiocarcinoma cells, with enhanced inhibition observed upon overexpression of four mitochondrial protein-encoding genes: Succinate Dehydrogenase Complex Assembly Factor 2 (SDHAF2), Mitochondrial Ribosomal Protein S34 (MRPS34), Mitochondrial Ribosomal Protein L11 (MRPL11), and Cytochrome c Oxidase Subunit 8A (COX8A) (67)

in: PubMed | Google Scholar | 1 Department of Thoracic Surgery and 2 Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, China

In energy metabolism, VIC supports the synthesis of carnitine, which is responsible for transporting fatty acids into mitochondria [7,10]

Stimulation of the Nrf2/ARE pathway is fundamental for the induction of antioxidant defense enzyme and the modulation of the intracellular GSH in response to stress (Liu et al., 2018a)