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Description

Further inspection of the longest VP35 molecules in the polymerase complexes revealed a four-helix bundle in the N lobe of the IID, in which the P XD in complex with N MoRE from either measles or Nipah virus could be superimposed onto that of both MARV and EBOV polymerases (Fig

10.1007/s40618-023-02258-2 259

We acknowledge support from a Dreyfus Foundation award (MPL), the Philomathia Foundation (MPL), an NSF CAREER award 2046159 (MPL), a McKnight Foundation award (MPL), a Simons Foundation Award (MPL), a Moore Foundation Award (MPL), a Brain Foundation Award (MPL),), a Heising-Simons Fellowship (MPL), and a Polymaths Award from Schmidt Sciences, LLC (MPL)

Response: We appreciate commenters' support of the proposed new add-on code

Modern pharmacokinetics has underscored the importance of a loading dose to achieve circulating values above bacterial Minimal Inhibitory Concentrations (MIC) to reduce the risk of resistance 6,7