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In addition to interfering with the progression of liver cirrhosis, another study (Liu et al., 2015) found that XYXD can also promote the apoptosis of macrophages in rats with renal histopathological damage caused by liver cirrhosis, thus reducing kidney damage in rats

^ a b Gray L.R., Tompkins S.C., Taylor E.B

This pathway influences matrix degradation by allowing fibroblasts to move through the matrix [147]

Notably, this cell death could be rescued by the addition of CoA [37], underscoring the critical role of CoA levels, alongside GSH levels, in the regulation of ferroptosis

Future studies must optimize ferroptosis inducers to enhance anti-tumor immunityfor example, combining ferroptosis modulators with immune checkpoint inhibitors (e.g., PD-1 blockers) to reverse immunosuppression