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Following an oral sucrose challenge, hCitrinmRNAtreated double KO mice further showed hepatic citrulline and plasma ammonium concentrations lower than those of double KO mice treated with a control mRNA, with concentrations of these metabolites maintained at levels similar to those measured in wildtype mice [118]

Nervous system of patients with epilepsy suffers severe damage because phagocytes rupture after penetrating the spinal cord tissue and invade the spinal fluid which further enters CSF

Much information related to mitochondrial health has surfaced in the literature

CRISPR Therapeutics is pushing beyond rare diseases and into cardiometabolic territory with its in vivo editing platformdebuting first-in-human data for CTX310 (targeting ANGPTL3) and preclinical results for CTX340 (targeting AGT) at AHA 2025