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Amplification of DHFR has also been observed in human lung tumors from patients treated with methotrexate

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This creates a feed-forward cycle: impaired autophagy and ELS function lead to defective mitophagy, which allows the persistence of damaged mitochondria that, in turn, generate inflammatory DAMPs

Intranasal administration of the peptide Selank regulates BDNF expression in the rat hippocampus in vivo