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doi: 10.1097/MED.0b013e328013da5b

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2.1.4.1 The engineering continuum: coupling constraint to functional agnosticism Virus-like particle functionalization strategies can be conceptualized along a continuum defined by the degree of thermodynamic coupling between scaffold assembly and antigen incorporation: Genetic fusion (the fully coupled regime): this remains the most structurally deterministic strategy, ensuring strict 1:1 stoichiometry and genetic stability

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The present review aims to summarize the available evidence regarding the key regulators involved in the modulation of the somatotroph axis in humans, presenting detailed molecular insights on the signaling cascades at play