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Without adequate VEGF signaling, wound healing stalls: fibroblasts deposit matrix without vascular support, creating avascular scar tissue rather than functional regeneration

69 MaY.MiroslavV.FreitasH

doi:10.1053/j.jrn.2024.03.009 101

A novel mechanism for the beneficial vascular effects of high-density lipoprotein cholesterol: enhanced vasorelaxation and increased endothelial nitric oxide synthase expression

While transcriptomic studies have highlighted shifts in lysosomal activity, redox balance, and lipid metabolism with increased passage number 17 , comprehensive mechanistic analyses linking these genetic changes to metabolic flux alterations remain lacking