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10.1038/cmi.2011.3 62 SuiJ.DemingM.RockxB.LiddingtonR

Subtle improvements often appear after 48 sessions (roughly 48 weeks), with more noticeable changes around 1012 weeks

[DOI] [PubMed] [Google Scholar] 18.Ursin R

demonstrated that Tom20 or Bax knockout effectively blocks ROS-induced pyroptosis, while antioxidant treatment significantly reduces Tom20 oxidation, Bax mitochondrial recruitment, and GSDME cleavage, further confirming that ROS serves as the central regulator of this signaling pathway (47)