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Chlebowski RT, Anderson GL, Aragaki AK, et al

Elevated inflammatory markers in these patients correlate with neuroinflammatory changes, microglial activation, and neuronal damage in the hippocampus and prefrontal cortex, leading to persistent cognitive deficits (Sonneville et al., 2023)

You should also contact your healthcare provider if you notice: New or worsening curvature A firm lump or scarring in the injection area Bleeding that does not stop with pressure Pain that feels unusual for you A response that is consistently too weak or too strong Any concern about your dose or technique Trimix should only be used as prescribed

ISBN 978-0-393-33624-5

Icing the calf muscles is a good way to do this and it helps to temporarily numb your pain as well