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AOD-9604 has demonstrated preservation of normal glucose metabolism in clinical trials, with no negative effects on blood sugar, insulin sensitivity, or diabetic markers

At the same time, B12 insufficiency in the liver leads to shrinking of the intestinal cells and malabsorption of nutrients (including B12 itself), leading to a cycle of worsening B12 deficiency

Oct 2016;109:29-40

Considering the utility of GPx mimics as potent ROS scavengers, a few of such compounds have been explored as potential radiation countermeasures to protect cells and tissues against radiation-induced toxicity

10.3390/ijerph20043596 [DOI] [PMC free article] [PubMed] [Google Scholar] 303.Kimura, Y., Tsukui, D