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Arrowhead plans to file a supplemental new drug application with the FDA for the broader severe hypertriglyceridemia indication before the end of 2026

(2) BaP binds to the ligand-activated transcription factor AhR, which evokes oxidative stress and inflammation response molecules in ECs via activating the AhR/ARNT/XRE, MEK/c-Jun, and MAPK/NF-kB/AP-1 signaling pathway

contraindications include coma, pancreatitis, ileus or gastrointestinal tract insufficiency

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193 These effects appear to be mediated by a Complex II-dependent mechanism that improves mitochondrial respiration and ATP production