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Importantly, the majority of sulforaphanes neuroprotective effects are mediated by NRF2, since the absence of NRF2 prevents sulforaphanes effects (Innamorato et al., 2008

Phenformin had an IC 50 of 1.81 M, and atpenin A5 an IC 50 of 0.45 M against the original Wuhan strain in Calu-3 cells without cellular toxicity and both compounds were similarly active against the Omicron variant

ALS-causing mutations significantly perturb the self-assembly and interaction with nucleic acid of the intrinsically disordered prion-like domain of TDP-43

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