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Figure 18 represents in vivo SCID and CD-1 mice tolerability assessment of conjugates at high doses, according to example 13

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Abnormal function of these diverse PV neurons affects high-frequency (gamma) neuronal synchronization within brain regions and cortico-thalamic network dynamic [60, 61], impacting sensory processing, attention, working memory, learning, social behavior, fear processing, motor coordination and learning, and contributing to hyperdopaminergia related to positive symptoms [62,63,64,65,66,67,68,69]