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Front Aging Neurosci (2016) 8:308

Micro-CT and histological staining of knee joints show that BCA prevents cartilage iron deposition and reduces KOA severity in iron-overloaded mice, suggesting new therapeutic avenues for KOA (171)

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Clinical studies show that while GLP-1 peptides like semaglutide and tirzepatide primarily reduce fat mass, some lean muscle is lost as well

In some cases, splenectomy has been efficacious in modifying the anemia, although hemolysis may continue as manifested by persistent reticulocytosis