glutathione plaquenil hyperpigmentation Brightening from Within: How Naturally Reduces Hyperpigmen – Setu Nutrition Hydroxychloroquine-related skin discoloration - PMC

AOP Development Strategy Context This AOP was developed for the project "CHRONIC TOXICITY OF PESTICIDES IN DRINKING WATER IN PARABA (TRIGGER): IDENTIFYING THE TRIGGERS OF A SILENT EPIDEMIC," financed by the "Fundao de Apoio Pesquisa do Estado da Paraba (FAPESQ-PB)." The project aims to understand how oxidative stress and reproductive toxicity can be triggered in animals by aquatic pollutants, such as atrazine Strategy The first step in developing this AOP was to conduct a literature review to gather toxicological data on the herbicide atrazine's impact on aquatic vertebrates in relation to oxidative stress and reproductive toxicity

PolimeniLDel BenMBarattaFPerriLAlbaneseFPastoriDet al

doi: 10.1054/arth.2001.23716

Under normal conditions NAPQI is metabolised by conjugation with glutathione to form cysteine and mercapturic acid conjugates

Thus, while biochemical endpoints converge, the initiating mechanisms and defense kinetics differ substantially