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Icotinib also was associated with fewer adverse events than gefitinib when considering all grades of reactions together (61% versus 70% respectively, p = 0.046).[7] The phase IV ISAFE trial evaluated 5,549 patients and showed icotinib to have an overall response rate of 30% and an adverse event rate of 31.5%.[8] This trial demonstrated consistent safety and toxicity profiles of icotinib observed in the ICOGEN trial

(2020) 140:182436.e7

References Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, et al

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Funct Integr Genomics 9:377396 Farrar K, Bryant D, Cope-Selby N (2014) Understanding and engineering beneficial plantmicrobe interactions: plant growth promotion in energy crops